BRCA1 and BRCA2 rearrangements in Brazilian individuals with Hereditary Breast and Ovarian Cancer Syndrome

BRCA1 and BRCA2 rearrangements in Brazilian individuals with Hereditary Breast and Ovarian Cancer Syndrome

Abstract Approximately 5-10% of breast cancers are caused by germline mutations in high penetrance predisposition genes. Among these, BRCA1 and BRCA2, which are associated with the Hereditary Breast and Ovarian Cancer (HBOC) syndrome, are the most frequently affected genes. Recent studies confirm th...

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Bibliographic Details
Main Authors: Ingrid Petroni Ewald, Silvia Liliana Cossio, Edenir Inez Palmero, Manuela Pinheiro, Ivana Lucia de Oliveira Nascimento, Taisa Manuela Bonfim Machado, Kiyoko Abe Sandes, Betânia Toralles, Bernardo Garicochea, Patricia Izetti, Maria Luiza Saraiva Pereira, Hugo Bock, Fernando Regla Vargas, Miguel Ângelo Martins Moreira, Ana Peixoto, Manuel R. Teixeira, Patricia Ashton-Prolla
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2016-06-01
Series:Genetics and Molecular Biology
Subjects:
Breast cancer
Hereditary Breast and Ovarian Cancer syndrome
gene rearrangements
BRCA gene
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200223&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200223&lng=en&tlng=en

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