Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

A high mutation rate leading to tumor cell heterogeneity is a driver of malignancy in human cancers. Paradoxically, however, genomic instability can also render tumors vulnerable to therapeutic attack. Thus, targeting DNA repair may induce an intolerable level of DNA damage in tumor cells. BRCA2 med...

Full description

Bibliographic Details
Main Authors: Mateusz Rytelewski, Peter J Ferguson, Saman Maleki Vareki, Rene Figueredo, Mark Vincent, James Koropatnick
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense
BRCA2
complementary lethality
DNA repair
drug sensitivity
TS
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301408

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301408

Similar Items