CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats. Plasma blood urea nitrogen (Bun), plasma creatinine (CREA), urine CREA and protein in the rats were quantitatively measured. Re...

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Bibliographic Details
Main Authors: Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao, Chun Wang
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Paeoniflorin-6′-O-benzene sulfonate
Methotrexate
Renal injury
Organic anion transporter-3
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000190

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http://www.sciencedirect.com/science/article/pii/S1347861321000190

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