Comparison of Endothelium-Related Responses to Nucleotides of Dog and Monkey Cerebral Arteries

We compared mechanical responses to uridine-5′triphosphate (UTP) and 2-(methylthio)adenosine-5′diphosphate (2MeSADP) of cerebral arteries isolated from dogs and monkeys. In the dog, UTP induced endothelium-independent contraction, whereas 2MeSADP induced endothelium-dependent relaxation that was abo...

Full description

Bibliographic Details
Main Authors: Ayman Geddawy, Takashi Shimosato, Masashi Tawa, Takeshi Imamura, Tomio Okamura
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319310084