The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease. Kinase hyperactivity may be a consistent feature of ALS and FTLD-TDP, as phosphorylated TDP-43 is n...

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Main Authors: Nicole F Liachko, Pamela J McMillan, Timothy J Strovas, Elaine Loomis, Lynne Greenup, Jill R Murrell, Bernardino Ghetti, Murray A Raskind, Thomas J Montine, Thomas D Bird, James B Leverenz, Brian C Kraemer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4256087?pdf=render

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http://europepmc.org/articles/PMC4256087?pdf=render

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