Glycoprotein IIb/IIIa and P2Y12 Induction by Oligochitosan Accelerates Platelet Aggregation

Platelet membrane receptor glycoprotein IIb/IIIa (gpiibiiia) is a receptor detected on platelets. Adenosine diphosphate (ADP) activates gpiibiiia and P2Y12, causing platelet aggregation and thrombus stabilization during blood loss. Chitosan biomaterials were found to promote surface induced hemostas...

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Bibliographic Details
Main Authors: Mercy Halleluyah Periayah, Ahmad Sukari Halim, Nik Soriani Yaacob, Arman Zaharil Mat Saad, Abdul Rahim Hussein, Ahmad Hazri Abdul Rashid, Zanariah Ujang
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/653149