Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motone...

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Bibliographic Details
Main Authors: María de Lourdes Martínez-Silva, Rebecca D Imhoff-Manuel, Aarti Sharma, CJ Heckman, Neil A Shneider, Francesco Roselli, Daniel Zytnicki, Marin Manuel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
electrophysiology
in vivo intracellular recordings
motor neuron
motoneuron
firing properties
Online Access:https://elifesciences.org/articles/30955

Internet

https://elifesciences.org/articles/30955

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