Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.

Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci.

We carried out genome-wide association (GWA) studies in inbred mouse strains characterized for their lung tumor susceptibility phenotypes (spontaneous or urethane-induced) with panels of 12,959 (13K) or 138,793 (140K) single-nucleotide polymorphisms (SNPs). Above the statistical thresholds, we detec...

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Bibliographic Details
Main Authors: Giacomo Manenti, Antonella Galvan, Angela Pettinicchio, Gaia Trincucci, Elena Spada, Anna Zolin, Silvano Milani, Anna Gonzalez-Neira, Tommaso A Dragani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2614123?pdf=render

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http://europepmc.org/articles/PMC2614123?pdf=render

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