Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development

Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development

Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs) and was recently discovered to regulate the angiogenic transcriptome,...

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Bibliographic Details
Main Authors: Miranda R. Sun, Hannah M. Chung, Veronika Matsuk, Dustin M. Fink, Matthew J. Stebbins, Sean P. Palecek, Eric V. Shusta, Robert J. Lipinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
perivascular
pericyte
cranial neural crest
Sonic hedgehog
orofacial clefting
microvascular morphogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.590539/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.590539/full

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