Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects

Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects

Irradiation of tumors generates danger signals and inflammatory cytokines that promote the off-target bystander and abscopal effects, evident especially when radiotherapy is administered in combination with the immune checkpoint inhibitors (ICI). The underlying mechanisms are not fully understood; h...

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Bibliographic Details
Main Authors: Tanja Jesenko, Masa Bosnjak, Bostjan Markelc, Gregor Sersa, Katarina Znidar, Loree Heller, Maja Cemazar
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
DNA sensors
irradiation
bystander effect
abscopal effects
immunostimulation
Online Access:https://www.mdpi.com/2072-6694/12/11/3365

Internet

https://www.mdpi.com/2072-6694/12/11/3365

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