Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

Abstract Oesophageal cancer (OC) has high mortality. This study aims at determining the feasibility of liquid biopsies for genomic profiling in early stage OC, comparing two different technologies for mutational analysis in circulating cell -free DNA (ccfDNA) and evaluating the clinical impact of th...

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Bibliographic Details
Main Authors: Helen Pasternack, Jana Fassunke, Patrick Sven Plum, Seung-Hun Chon, Daniel Alexander Hescheler, Asmae Gassa, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Sven Perner, Michael Hallek, Reinhard Büttner, Elfriede Bollschweiler, Arnulf Heinrich Hölscher, Alexander Quaas, Thomas Zander, Jonathan Weiss, Hakan Alakus
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Somatic Alterations
Primary Stage
ccfDNA
Simultaneous Blood Samples
Post-surgical Outcomes
Online Access:https://doi.org/10.1038/s41598-018-33027-4

Internet

https://doi.org/10.1038/s41598-018-33027-4

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