Dealing With BRCA1/2 Unclassified Variants in a Cancer Genetics Clinic: Does Cosegregation Analysis Help?

Dealing With BRCA1/2 Unclassified Variants in a Cancer Genetics Clinic: Does Cosegregation Analysis Help?

Background: Detection of variants of uncertain significance (VUSs) in BRCA1 and BRCA2 genes poses relevant challenges for counseling and managing patients. VUS carriers should be managed similarly to probands with no BRCA1/2 variants detected, and predictive genetic testing in relatives is discourag...

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Bibliographic Details
Main Authors: Roberta Zuntini, Simona Ferrari, Elena Bonora, Francesco Buscherini, Benedetta Bertonazzi, Mina Grippa, Lea Godino, Sara Miccoli, Daniela Turchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Genetics
Subjects:
BRCA1
BRCA2
VUS
breast cancer
ovarian cancer
hereditary cancer
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00378/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00378/full

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