A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis

A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis

We examined whether hypoxic exposure prior to the event of transplantation would have a positive or negative effect upon later islet graft function. Mouse islets exposed to hypoxic culture were transplanted into syngeneic recipients. Islet graft function, β-cell physiology, as well as molecular chan...

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Bibliographic Details
Main Authors: James Cantley, Stacey N. Walters, Min-Ho Jung, Anita Weinberg, Mark J. Cowley, P. Tess Whitworth, Warren Kaplan, Wayne J. Hawthorne, Philip J. O'connell, Gordon Weir, Shane T. Grey
Format: Article
Language:English
Published: SAGE Publishing 2013-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X658728

Internet

https://doi.org/10.3727/096368912X658728

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