Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

Summary: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tu...

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Bibliographic Details
Main Authors: Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Tanja Musch, Axel Benner, Yehudit Bergman, Sebastian M. Dieter, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, Frank Lyko
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307915

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http://www.sciencedirect.com/science/article/pii/S2211124718307915

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