Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

Successful immunotherapy for melanoma depends on the recruitment of effector CD8+ T cells to the tumor microenvironment. Factors contributing to T cell regulation in melanoma have recently been recognized, including the stimulator of interferon genes (STING). Agents that can activate STING or enhanc...

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Bibliographic Details
Main Authors: Praveen K. Bommareddy, Andrew Zloza, Samuel D. Rabkin, Howard L. Kaufman
Format: Article
Language:English
Published: Taylor & Francis Group 2019-07-01
Series:OncoImmunology
Subjects:
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1591875