Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease

Abstract Background Blood markers indicative of neurodegeneration (neurofilament light chain; NFL), Alzheimer’s disease amyloid pathology (amyloid-β; Aβ), and neuroinflammation (kynurenine pathway; KP metabolites) have been investigated independently in neurodegenerative diseases. However, the assoc...

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Bibliographic Details
Main Authors: Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Neuroinflammation
Subjects:
Blood markers
Neuroinflammation
Neurodegeneration
Alzheimer’s disease
Neurofilament light chain
Amyloid-beta
Online Access:http://link.springer.com/article/10.1186/s12974-019-1567-4

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http://link.springer.com/article/10.1186/s12974-019-1567-4

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