Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Abstract The amyloid cascade hypothesis posits that the initiating event in Alzheimer’s disease (AD) is the aggregation and deposition of the β-amyloid (Aβ) peptide, which is a proteolytic cleavage product of the amyloid precursor protein (APP). Mounting evidence suggests that the formation and spre...

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Bibliographic Details
Main Authors: Alejandro Ruiz-Riquelme, Heather H. C. Lau, Erica Stuart, Adrienn N. Goczi, Zhilan Wang, Gerold Schmitt-Ulms, Joel C. Watts
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
Aβ
Amyloid
Prion-like transmission
Propagation
Knock-in mice
Cerebral amyloid angiopathy
Online Access:http://link.springer.com/article/10.1186/s40478-018-0529-x

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http://link.springer.com/article/10.1186/s40478-018-0529-x

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