Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview

Do asian patients require only half of the clozapine dose prescribed for caucasians? A critical overview

Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dose (C/D) ratios typically range between 0.60 (male...

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Bibliographic Details
Main Authors: Jose de Leon, Anto P Rajkumar, Arun R Kaithi, Georgios Schoretsanitis, John M Kane, Chuan-Yue Wang, Yi-Lang Tang, Shih-Ku Lin, Kyung Sue Hong, Saeed Farooq, Chee H Ng, Can-Jun Ruan, Chittaranjan Andrade
Format: Article
Language:English
Published: SAGE Publishing 2020-01-01
Series:Indian Journal of Psychological Medicine
Subjects:
asian continental ancestry group/genetics
blood
cyp1a2
clozapine
drug labeling
india
pharmacokinetics
sex
smoking
Online Access:http://www.ijpm.info/article.asp?issn=0253-7176;year=2020;volume=42;issue=1;spage=4;epage=10;aulast=de

Internet

http://www.ijpm.info/article.asp?issn=0253-7176;year=2020;volume=42;issue=1;spage=4;epage=10;aulast=de

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