Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease Brain

Oxidative Insults Are Associated with Apolipoprotein E Genotype in Alzheimer's Disease Brain

The ϵ4 allele of the apolipoprotein E gene (APOE) is associated with sporadic and familial late-onset Alzheimer's disease (AD). Oxidative stress is believed to play an important role in neuronal dysfunction and cell death in AD. We now provide evidence that in the hippocampus of AD, the level o...

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Bibliographic Details
Main Authors: Charles Ramassamy, Diana Averill, Uwe Beffert, Louise Theroux, Suzanne Lussier-Cacan, Jeffrey S. Cohn, Yves Christen, Alain Schoofs, Jean Davignon, Judes Poirier
Format: Article
Language:English
Published: Elsevier 2000-02-01
Series:Neurobiology of Disease
Subjects:
lipid peroxidation
glutathione
glutathione peroxidase
catalase
apolipoprotein E concentration
hippocampus.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902735

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http://www.sciencedirect.com/science/article/pii/S0969996199902735

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