Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats

Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats

Background/Aims: The apoptosis of activated hepatic stellate cells (HSCs) is the central event in the reversal of liver fibrosis. K63 de-ubiquitinated receptor-interacting protein (RIP)1 promotes apoptosis in tumor necrosis factor (TNF)-α signaling pathway. In the previous study, we have proved that...

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Bibliographic Details
Main Authors: Bin Li, Meng Cong, Yanan Zhu, Ying Xiong, Wenyi Jin, Yang Wan, Yunjiao Zhou, Ying Ao, Hui Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Indole-3-carbinol
Hepatic stellate cells
Receptor-interacting protein 1
K63 de-ubiquitination
Cylindromatosis
Online Access:http://www.karger.com/Article/FullText/470650

Internet

http://www.karger.com/Article/FullText/470650

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