Bioorganic Studies in AIDS: Synthetic Antifungals Against Pneumocystis carinii Based on the Multivalency Concept

Bioorganic Studies in AIDS: Synthetic Antifungals Against Pneumocystis carinii Based on the Multivalency Concept

Abstract: We report the syntheses of antifungals containing the novel pharmacophores: oxaziridines, sulfonyloxaziridines, nitrones and nitronyl nitroxides. We hypothesized that multiple copies of the pharmacophore per molecule might be a prerequisite to enhance efficacy against the opportunistic pat...

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Bibliographic Details
Main Authors: Valeria Balogh-Nair, Christian R. Gonzalez, Cunxiang Chen, Langu Peng
Format: Article
Language:English
Published: MDPI AG 2002-11-01
Series:International Journal of Molecular Sciences
Subjects:
AIDS
opportunistic infections
Pneumocystis carinii
multivalency in drug design
antifungals
oxaziridines
sulfonyloxaziridines
nitrones
nitronyl nitroxides
Online Access:http://www.mdpi.com/1422-0067/3/11/1145/

Internet

http://www.mdpi.com/1422-0067/3/11/1145/

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