The in vivo role of Rev1 in mutagenesis and carcinogenesis

The in vivo role of Rev1 in mutagenesis and carcinogenesis

Abstract Translesion synthesis (TLS) is an error-prone pathway required to overcome replication blockage by DNA damage. Aberrant activation of TLS has been suggested to play a role in tumorigenesis by promoting genetic mutations. However, the precise molecular mechanisms underlying TLS-mediated tumo...

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Bibliographic Details
Main Authors: Megumi Sasatani, Elena Karamfilova Zaharieva, Kenji Kamiya
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Genes and Environment
Subjects:
Translesion synthesis
Rev1
Mutagenesis
Tumorigenesis
Online Access:http://link.springer.com/article/10.1186/s41021-020-0148-1

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http://link.springer.com/article/10.1186/s41021-020-0148-1

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