Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

Amyloid-β Plaques in Clinical Alzheimer’s Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity

Alzheimer’s disease (AD) is a neurodegenerative disorder with clinical manifestations of progressive memory decline and loss of executive function and language. AD affects an estimated 5.3 million Americans alone and is the most common form of age-related dementia with a rapidly growing prevalence a...

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Bibliographic Details
Main Authors: Norelle C. Wildburger, Frank Gyngard, Christelle Guillermier, Bruce W. Patterson, Donald Elbert, Kwasi G. Mawuenyega, Theresa Schneider, Karen Green, Robyn Roth, Robert E. Schmidt, Nigel J. Cairns, Tammie L. S. Benzinger, Matthew L. Steinhauser, Randall J. Bateman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neurology
Subjects:
Alzheimer’s disease
Aβ plaques
plaque dynamics
stable isotope tracer
SILK–SIMS
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00169/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00169/full

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