A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation

A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation

Glioblastoma multiforme (GBM) is a highly heterogeneous disease, which is initiated and sustained by various molecular alterations in an array of signal transduction pathways. Heat-shock protein 90 (Hsp90) is a molecular chaperone and is critically implicated in folding and activation of a diverse g...

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Bibliographic Details
Main Authors: Hao Chen, Yuanying Gong, Yufang Ma, Reid C. Thompson, Jialiang Wang, Zhixiang Cheng, Lixia Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
radiation resistance
Hsp90 inhibitor
molecular pharmacology
DNA damage response
ER stress
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00974/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00974/full

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