Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides associated with Alzheimer's disease (AD). Previous studies have indicated that BACE is elevated in the frontal cortex of AD patients. Golgi-localized γ-ear containing...

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Bibliographic Details
Main Authors: Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A. Bellingham, Michael Ho, Jiangli Tan, Andrew F. Hill, Colin L. Masters, Catriona McLean, Geneviève Evin
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neurobiology of Disease
Subjects:
BACE1
Secretase
Amyloid precursor protein
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100091X

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http://www.sciencedirect.com/science/article/pii/S096999611100091X

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