Next generation of immune checkpoint therapy in cancer: new developments and challenges

Next generation of immune checkpoint therapy in cancer: new developments and challenges

Abstract Immune checkpoints consist of inhibitory and stimulatory pathways that maintain self-tolerance and assist with immune response. In cancer, immune checkpoint pathways are often activated to inhibit the nascent anti-tumor immune response. Immune checkpoint therapies act by blocking or stimula...

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Bibliographic Details
Main Authors: Julian A. Marin-Acevedo, Bhagirathbhai Dholaria, Aixa E. Soyano, Keith L. Knutson, Saranya Chumsri, Yanyan Lou
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Hematology & Oncology
Subjects:
Cancer
Immunotherapy
Tumor microenvironment
Immune evasion
Cytotoxic T lymphocytes
Online Access:http://link.springer.com/article/10.1186/s13045-018-0582-8

Internet

http://link.springer.com/article/10.1186/s13045-018-0582-8

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