Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect

Type 2 diabetes increases oocyte mtDNA mutations which are eliminated in the offspring by bottleneck effect

Abstract Background Diabetes induces many complications including reduced fertility and low oocyte quality, but whether it causes increased mtDNA mutations is unknown. Methods We generated a T2D mouse model by using high-fat-diet (HFD) and Streptozotocin (STZ) injection. We examined mtDNA mutations...

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Bibliographic Details
Main Authors: Li Li, Chang-Sheng Wu, Guan-Mei Hou, Ming-Zhe Dong, Zhen-Bo Wang, Yi Hou, Heide Schatten, Gui-Rong Zhang, Qing-Yuan Sun
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Reproductive Biology and Endocrinology
Subjects:
Diabetes
Oocyte
mtDNA mutation
Bottleneck
Online Access:http://link.springer.com/article/10.1186/s12958-018-0423-1

Internet

http://link.springer.com/article/10.1186/s12958-018-0423-1

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