Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

Zika virus (ZIKV) can be associated with neurological impairment in children and adults. To reach the central nervous system, viruses have to cross the blood-brain barrier (BBB), a multicellular system allowing a tight separation between the bloodstream and the brain. Here, we show that ZIKV infects...

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Bibliographic Details
Main Authors: Marion Clé, Caroline Desmetz, Jonathan Barthelemy, Marie-France Martin, Orianne Constant, Ghizlane Maarifi, Vincent Foulongne, Karine Bolloré, Yaël Glasson, Frédéric De Bock, Marine Blaquiere, Lucie Dehouck, Nelly Pirot, Edouard Tuaillon, Sébastien Nisole, Fatiha Najioullah, Philippe Van de Perre, André Cabié, Nicola Marchi, Fabien Gosselet, Yannick Simonin, Sara Salinas
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
zika virus
blood-brain barrier
cell adhesion molecules
leukocyte recruitment
Online Access:https://doi.org/10.1128/mBio.01183-20

Internet

https://doi.org/10.1128/mBio.01183-20

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