Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage

Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage

Hyaluronic acid (HA) is used clinically to treat osteoarthritis (OA), but its pharmacological effects under hypoxic conditions remain unclear. Articular chondrocytes in patients with OA are exposed to a hypoxic environment. This study investigated whether hypoxia could potentiate the anabolic effect...

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Bibliographic Details
Main Authors: Shohei Ichimaru, Shuji Nakagawa, Yuji Arai, Tsunao Kishida, Masaharu Shin-Ya, Kuniaki Honjo, Shinji Tsuchida, Hiroaki Inoue, Hiroyoshi Fujiwara, Seiji Shimomura, Osam Mazda, Toshikazu Kubo
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia-inducible factor 1 α
hyaluronic acid
CD44
articular cartilage
extracellular matrix
Online Access:http://www.mdpi.com/1422-0067/17/7/1013

Internet

http://www.mdpi.com/1422-0067/17/7/1013

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