Prevalence and evolution of low frequency HIV drug resistance mutations detected by ultra deep sequencing in patients experiencing first line antiretroviral therapy failure.

Prevalence and evolution of low frequency HIV drug resistance mutations detected by ultra deep sequencing in patients experiencing first line antiretroviral therapy failure.

OBJECTIVES: Clinical relevance of low-frequency HIV-1 variants carrying drug resistance associated mutations (DRMs) is still unclear. We aimed to study the prevalence of low-frequency DRMs, detected by Ultra-Deep Sequencing (UDS) before antiretroviral therapy (ART) and at virological failure (VF), i...

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Bibliographic Details
Main Authors: Marie-Anne Vandenhende, Pantxika Bellecave, Patricia Recordon-Pinson, Sandrine Reigadas, Yannick Bidet, Mathias Bruyand, Fabrice Bonnet, Estibaliz Lazaro, Didier Neau, Hervé Fleury, François Dabis, Philippe Morlat, Bernard Masquelier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903565?pdf=render

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http://europepmc.org/articles/PMC3903565?pdf=render

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