Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis

Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis

Reinforcing defective tolerogenic processes slows progression of autoimmune (AI) diseases and has potential to promote drug-free disease remission. Previously, we reported that DNA nanoparticles (DNPs) and cyclic dinucleotides (CDNs) slow progression of experimental autoimmune encephalomyelitis (EAE...

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Bibliographic Details
Main Authors: Henrique Lemos, Eslam Mohamed, Rong Ou, Caroline McCardle, Xiaozhong Zheng, Kris McGuire, Natalie Z. M. Homer, Damian J. Mole, Lei Huang, Andrew L. Mellor
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
STING
IDO
immunotherapy
EAE
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01256/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01256/full

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