HP-1γ controls high-affinity antibody response to T-dependent antigens

HP-1γ controls high-affinity antibody response to T-dependent antigens

In vitro observations suggest a role for the mouse heterochromatin protein 1 γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ positively regulates the germinal center reaction and high-affinity antibody...

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Bibliographic Details
Main Authors: Ngoc eHa, Hung Duc Pham, Aliakbar eShahsafaei, Chie eNaruse, Masahide eAsano, To-Ha eThai
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
Adaptive Immunity
epigenetics
Chromatin remodeling
germinal center response
CD8+ regulatory T cells.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00271/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00271/full

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