Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats.

Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats.

BACKGROUND:Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo. Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (DRG) in rats. METHODOLOGY/PRINCIPAL FINDINGS:...

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Bibliographic Details
Main Authors: Meng-Yen Li, Feng-Jie Lai, Li-Jin Hsu, Chen-Peng Lo, Ching-Li Cheng, Sing-Ru Lin, Ming-Hui Lee, Jean-Yun Chang, Dudekula Subhan, Ming-Shu Tsai, Chun-I Sze, Subbiah Pugazhenthi, Nan-Shan Chang, Shur-Tzu Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2771921?pdf=render

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http://europepmc.org/articles/PMC2771921?pdf=render

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