Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene

Noncanonical Expression of a Murine Cytomegalovirus Early Protein CD8 T-Cell Epitope as an Immediate Early Epitope Based on Transcription from an Upstream Gene

Viral CD8 T-cell epitopes, represented by viral peptides bound to major histocompatibility complex class-I (MHC-I) glycoproteins, are often identified by “reverse immunology”, a strategy not requiring biochemical and structural knowledge of the actual viral protein from which they are derived by ant...

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Bibliographic Details
Main Authors: Annette Fink, Julia K. Büttner, Doris Thomas, Rafaela Holtappels, Matthias J. Reddehase, Niels A. W. Lemmermann
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Viruses
Subjects:
antigenic peptides
antigen presentation
CD8 T cell epitope
gene expression
immediate-early protein
murine CMV ORF m164
open reading frame
RACE mapping
reverse immunology
transcription start site
translation start site
Online Access:http://www.mdpi.com/1999-4915/6/2/808

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http://www.mdpi.com/1999-4915/6/2/808

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