Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa

Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa

Topoisomerases are required for alleviating supercoiling of DNA during transcription and replication. Recent evidence suggests that supercoiling of bacterial DNA can affect bacterial pathogenicity. To understand the potential regulatory role of a topoisomerase I (TopA) in Pseudomonas aeruginosa, we...

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Bibliographic Details
Main Authors: Rong Yan, Shikun Hu, Ning Ma, Peiqing Song, Qingqing Liang, Huiqun Zhang, Yanqi Li, Lixin Shen, Kangmin Duan, Lin Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
DNA Topoisomerase
Pyocyanin
Pseudomonas aeruginosa
prtN
type III secretion system
antibiotic susceptibility
biofilm
Online Access:http://www.mdpi.com/1422-0067/20/5/1116

Internet

http://www.mdpi.com/1422-0067/20/5/1116

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