Clinical evaluation of a dedicated next generation sequencing panel for routine glioma diagnostics

Clinical evaluation of a dedicated next generation sequencing panel for routine glioma diagnostics

Abstract Since 2013 next-generation sequencing (NGS) targeting genes mutated in diffuse gliomas is part of routine diagnostics in our institute. In the present report, we evaluate the use of this custom tailored NGS platform on 434 samples. The NGS panel assesses mutations in ATRX, CIC, EGFR, FUBP1,...

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Bibliographic Details
Main Authors: Nathalie E. Synhaeve, Martin J. van den Bent, Pim J. French, Winand N. M. Dinjens, Peggy N. Atmodimedjo, Johan M. Kros, R. Verdijk, Clemens M. F. Dirven, Hendrikus J. Dubbink
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Acta Neuropathologica Communications
Subjects:
Glioma
Molecular diagnostics
Next-generation-sequencing
Online Access:http://link.springer.com/article/10.1186/s40478-018-0633-y

Internet

http://link.springer.com/article/10.1186/s40478-018-0633-y

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