Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives
The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes, mTORC1 and mTORC2, plays a central role in the regulation of cellular growth, metabolism and migration. A dysregulation of the mTOR pathway has in turn been implicated in several pathological conditions includin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00395/full |