Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.

Deregulation of hepatic insulin sensitivity induced by central lipid infusion in rats is mediated by nitric oxide.

Deregulation of hypothalamic fatty acid sensing lead to hepatic insulin-resistance which may partly contribute to further impairment of glucose homeostasis.We investigated here whether hypothalamic nitric oxide (NO) could mediate deleterious peripheral effect of central lipid overload. Thus we infus...

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Bibliographic Details
Main Authors: Nicolas Marsollier, Nadim Kassis, Karima Mezghenna, Maud Soty, Xavier Fioramonti, Amélie Lacombe, Aurélie Joly, Bruno Pillot, Carine Zitoun, José Vilar, Gilles Mithieux, René Gross, Anne-Dominique Lajoix, Vanessa Routh, Christophe Magnan, Céline Cruciani-Guglielmacci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2721417?pdf=render

Internet

http://europepmc.org/articles/PMC2721417?pdf=render

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