Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

ABSTRACT To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quality compared with the founder Sprague–Dawley (SD) rat...

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Bibliographic Details
Main Authors: Nancy S Krieger, Luojing Chen, Jennifer Becker, Sean DeBoyace, Hongwei Wang, Murray J Favus, David A Bushinsky
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:JBMR Plus
Subjects:
GENETIC ANIMAL MODELS
OSTEOBLASTS
OSTEOCLASTS
STROMAL/STEM CELLS
DISORDERS OF CALCIUM AND PHOSPHATE METABOLISM
Online Access:https://doi.org/10.1002/jbm4.10350

Internet

https://doi.org/10.1002/jbm4.10350

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