Generation of An Endogenous FGFR2–BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells

Generation of An Endogenous FGFR2–BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells

Fibroblast growth factor receptor 2 (<i>FGFR2</i>) gene fusions are <i>bona fide</i> oncogenic drivers in 10–15% of intrahepatic cholangiocarcinoma (CCA), yet currently there are no cell lines publically available to study endogenous <i>FGFR2</i> gene fusions. The...

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Bibliographic Details
Main Authors: Andreas Reicher, Antoneicka L Harris, Felix Prinz, Tobias Kiesslich, Miaoyan Wei, Rupert Öllinger, Roland Rad, Martin Pichler, Lawrence N Kwong
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR
cholangiocarcinoma
<i>FGFR2</i>
fusion
inversion
Online Access:https://www.mdpi.com/1422-0067/21/7/2460

Internet

https://www.mdpi.com/1422-0067/21/7/2460

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