Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses

Influence of a Hyperglycemic Microenvironment on a Diabetic Versus Healthy Rat Vascular Endothelium Reveals Distinguishable Mechanistic and Phenotypic Responses

Hyperglycemia is a critical factor in the development of endothelial dysfunction in type 2 diabetes mellitus (T2DM). Whether hyperglycemic states result in a disruption of similar molecular mechanisms in endothelial cells under both diabetic and non-diabetic states, remains largely unknown. This stu...

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Bibliographic Details
Main Authors: Dhanush Haspula, Andrew K. Vallejos, Timothy M. Moore, Namrata Tomar, Ranjan K. Dash, Brian R. Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
endothelium
hyperglycemia
diabetes
cardiovascular disease
mitochondrial function
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00558/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00558/full

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