HIF2alpha-Associated Pseudohypoxia Promotes Radioresistance in Pheochromocytoma: Insights from 3D Models

HIF2alpha-Associated Pseudohypoxia Promotes Radioresistance in Pheochromocytoma: Insights from 3D Models

Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare neuroendocrine tumors arising from chromaffin tissue located in the adrenal or ganglia of the sympathetic or parasympathetic nervous system. The treatment of non-resectable or metastatic PCCs/PGLs is still limited to palliative measures, incl...

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Bibliographic Details
Main Authors: Verena Seifert, Susan Richter, Nicole Bechmann, Michael Bachmann, Christian G. Ziegler, Jens Pietzsch, Martin Ullrich
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
paraganglioma
radionuclide therapy
lutetium-177
spheroid control dose
SCD<sub>50</sub>
spheroid re-growth
Online Access:https://www.mdpi.com/2072-6694/13/3/385

Internet

https://www.mdpi.com/2072-6694/13/3/385

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