GSK-3 and mitochondria in cancer cells

GSK-3 is a multifunctional kinase that is located in the cytosol, nucleus and mitochondria of all cell types, and it is involved in the pathogenesis of a variety of diseases. In cancer, GSK-3 modulates the response of the cell death machinery to stress stimuli, including chemotherapeutics. Mitochond...

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Bibliographic Details
Main Authors: Andrea eRasola, Federica eChiara
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Oncology
Subjects:
ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00016/full