Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression

Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression

Background/Aims: Major depressive disorder is a common disease with serious morbidity, including increased risk of death from suicide. Major depressive disorder is treated with antidepressants. However, the molecular targets of antidepressants remained ill-defined and require further elucidation. Me...

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Bibliographic Details
Main Authors: Heike Grassmé, Peter L. Jernigan, Richard S. Hoehn, Barbara Wilker, Matthias Soddemann, Michael J. Edwards, Christian P. Müller, Johannes Kornhuber, Erich Gulbins
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-12-01
Series:Neurosignals
Subjects:
p38 Kinase
Neurogenesis
Ceramide
Acid sphingomyelinase
Antidepressants
Online Access:http://www.karger.com/Article/FullText/442606

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http://www.karger.com/Article/FullText/442606

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