Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

BackgroundHypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that result in the development of renal interstitial fibrosis and subsequent chronic renal failure. Nonetheless, the kidney possesses a self-protection mechanism under a certain degree of hypoxia and this mecha...

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Bibliographic Details
Main Authors: Yaya Xu, Xiangmei Kong, Jiru Li, Tiantian Cui, Yifan Wei, Jiayue Xu, Yueniu Zhu, Xiaodong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
kidney injury
VEGF
HIF-1
chronic hypoxia
vascularization
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.690496/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.690496/full

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