Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.

Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl- level...

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Bibliographic Details
Main Authors: Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001355

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https://doi.org/10.1371/journal.pbio.3001355

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