Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia

Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia

Abstract Spinocerebellar ataxia (SCA) 42 is caused by a mutation in CACNA1G, which encodes the low voltage-gated calcium channel CaV3.1 (T-type). Patients with SCA42 exhibit a pure form of cerebellar ataxia. We encountered a patient with the p.Arg1715His mutation, suffering from intractable resting...

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Bibliographic Details
Main Authors: Naoyuki Hara, Hiroyuki Morino, Yukiko Matsuda, Kenichi Satoh, Kouichi Hashimoto, Hirofumi Maruyama, Hideshi Kawakami
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Brain
Subjects:
Spinocerebellar ataxia
SCA42
CACNA1G
T-type calcium channel
CaV3.1
Tremor
Online Access:http://link.springer.com/article/10.1186/s13041-020-00700-7

Internet

http://link.springer.com/article/10.1186/s13041-020-00700-7

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