The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries. The vasculopathy is accompanied by perivascular inflammation and increased protease levels, with neutrophil elastase...

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Bibliographic Details
Main Authors: Shalina Taylor, Omar Dirir, Roham T. Zamanian, Marlene Rabinovitch, A. A. Roger Thompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2018.00217/full