Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR

Abstract Development of resistance to platinum and poly(ADP‐ribose) polymerase inhibitors via secondary BRCA gene mutations that restore functional homologous recombination has been observed in a number of cancer types. Here we report a case of somatic BRCA2 mutation in a patient with high grade ser...

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Bibliographic Details
Main Authors: Saira Khalique, Stephen J Pettitt, Ger Kelly, Nina Tunariu, Rachael Natrajan, Susana Banerjee, Christopher J Lord
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:The Journal of Pathology: Clinical Research
Subjects:
PARP inhibitor
drug resistance
cancer
BRCA2
digital droplet PCR
Online Access:https://doi.org/10.1002/cjp2.146

Internet

https://doi.org/10.1002/cjp2.146

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