Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR
Abstract Development of resistance to platinum and poly(ADP‐ribose) polymerase inhibitors via secondary BRCA gene mutations that restore functional homologous recombination has been observed in a number of cancer types. Here we report a case of somatic BRCA2 mutation in a patient with high grade ser...
Main Authors: | Saira Khalique, Stephen J Pettitt, Ger Kelly, Nina Tunariu, Rachael Natrajan, Susana Banerjee, Christopher J Lord |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-01-01
|
Series: | The Journal of Pathology: Clinical Research |
Subjects: | |
Online Access: | https://doi.org/10.1002/cjp2.146 |
Similar Items
-
The characteristics of determination of BRCA1 and BRCA2 mutations in serous ovarian cancer
by: I A Demidova
Published: (2017-01-01) -
Cytotoxic and targeted therapy for BRCA1/2-driven cancers
by: Evgeny N. Imyanitov
Published: (2021-08-01) -
PARP Inhibition by Flavonoids Induced Selective Cell Killing to BRCA2-Deficient Cells
by: Cathy Su, et al.
Published: (2017-10-01) -
Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era
by: Gabriel S. Macedo, et al.
Published: (2019-04-01) -
Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide
by: Yosuke Hirotsu, et al.
Published: (2020-05-01)